animal models
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animal model generation

Animal models are used virtually in all fields of biomedical research including regenerative medicine, oncology, embryology, functional genomics, biotechnology, and genome engineering. Rapid advancements in genome engineering with programmable nucleases have opened the capability to model in comparative animal species including large animals such as pigs, that may adequately replicate the human condition where traditional rodent models have deficiencies. Our model design team is experienced with multiple DNA-writing and DNA-editing technologies including CRISPR-Cas systems, TALENs, zinc finger nucleases (ZFN), meganucleases, gene targeting by homologous recombination and phage recombineering.  We have a reputation for advancing biomedical model generation in both rodents and livestock, and these animal models continue to play critical roles in translational research and the advancement of human health.  Please explore our animal modeling services below and contact us through our general inquiry or quote requests to address specific end-user application needs.

mouse models

Bespoke knockout, conditional knockout, knock-in mouse models via CRISPR/Cas9 or conventional gene targeting by homologous recombination

rat models

Customized BAC transgenic, knockout, conditional knockout, knock-in rat models via CRISPR/Cas9 and designer nucleases

pig models

Customized knockout, conditional knockout, knock-in swine models via CRISPR/Cas9 and somatic cell nuclear transfer (SCNT)

livestock models

Customized knockout, conditional knockout, knock-in livestock models via CRISPR/Cas9 and somatic cell nuclear transfer (SCNT)