![genome engineering genome engineering](/icons/Cell%20engineering.png)
genome engineering
NovoHelix has developed precise tools for writing and editing the genome for custom animal models, cell line models, and bacterial strain generation.
- donor/repair vector construction for CRISPR-Cas gene editing
- animal model generation
- CRISPR/Cas-coupled recombineering for industrial Escherichia coli strain engineering
- activity testing of guide RNAs
- targeted epigenetic modification – epigenomic editing
![animal models animal models](/icons/animal_model_icon.jpg)
animal models
Animal models are indispensable for biomedical research. NovoHelix designs customized genetic modifications in rodent (mouse, rats) and livestock (pigs, cows, sheep, goats) to generate novel animal models.
- CRISPR-Cas engineered rodent models -
- mouse embryonic stem cell gene targeting
- knockout, knock-in, conditional knockout, safe harbor biomedical modelsgenome editing in large animals
- somatic cell nuclear transfer (SCNT)
- BAC transgenic mouse & rat models
![stem cell models stem cell models](/icons/Stem%20cell-1.png)
stem cells
NovoHelix can model human disease in a dish by combining two powerful technologies: nuclear reprogramming to pluripotency and gene editing.
- gene edited iPS cells and isogenic controls
- ‘disease-in-a dish’ iPS cell line modeling
- reprogramming to generate iPS cells from samples
- stem cell products
- derivation of new mouse ES cell lines