• mouse • rat • pig • cow • goat

    animal models

  • tetraploid embryo complementation

    somatic cell nuclear transfer


  •    gene editing • prime editing • base editing • epigenetic editing

    simplify your editing strategy

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  • Custom DNA assembly for CRISPR & Gene Targeting Vectors

       conditional knockouts • knock-ins 

    active genetics/gene drives and more

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  • Recombineering for efficient DNA assembly of large DNA fragments

       BAC transgenics • strain engineering • MAGE • counterselection

tools & resources
genome engineering

genome engineering

NovoHelix has developed precise tools for writing and editing the genome for custom animal models, cell line models, and bacterial strain generation.

  • donor/repair vector construction for CRISPR-Cas gene editing
  • animal model generation
  • CRISPR/Cas-coupled recombineering for industrial  Escherichia coli strain engineering
  • activity testing of guide RNAs
  • targeted epigenetic modification – epigenomic editing
animal models

animal models

Animal models are indispensable for biomedical research. NovoHelix designs customized genetic modifications in rodent (mouse, rats) and livestock (pigs, cows, sheep, goats) to generate novel animal models.

  • CRISPR-Cas engineered rodent models - 
  • mouse embryonic stem cell gene targeting
  • knockout, knock-in, conditional knockout, safe harbor biomedical modelsgenome editing in large animals
  • somatic cell nuclear transfer (SCNT)
  • BAC transgenic mouse & rat models
stem cell models

stem cells

NovoHelix can model human disease in a dish by combining two powerful technologies: nuclear reprogramming to pluripotency and gene editing. 

  • gene edited iPS cells and isogenic controls
  • ‘disease-in-a dish’ iPS cell line modeling
  • reprogramming to generate iPS cells from samples
  • stem cell products
  • derivation of new mouse ES cell lines